Dr. Maike Kuhlmann, Research & Development, Beiersdorf AG

The science behind urea

How this ingredient can
restore hydration in foot skin

An interview with experts about urea

Hansaplast Centre for Research and Development
Hansaplast Centre for Research and Development

Dr. Ivan Bristow and Dr. Maike Kuhlmann are experts in keeping skin healthy and moisturised.

Dr Ivan Bristow and Dr Maike Kuhlmann are experts in keeping skin healthy and moisturized. Dr Bristow, an independent dermatological expert with extensive clinical experience, talks about the most common problems he encounters in practice and how urea works to replenish the moisture levels in our skin. Dr Kuhlmann, from Research & Development at Beiersdorf AG, who played an integral role in the development of the Hansaplast Regenerating Foot Cream with 10% UREA, tells us about the scientific background and testing that was conducted in order to create a product that offers optimal moisturization.

What foot problems do you see most in your podiatric practice? 

Dr. Ivan Bristow: The most common foot problem I see is thickened dry skin, or what we call hyperkeratosis in the profession. Hyperkeratosis nearly always starts as dry skin. One of the reasons for that is that we are standing on our feet all the time. The dry skin can then turn into hardened dry skin (hyperkeratosis), and that means it can become particularly uncomfortable and lead to problems.

Dr Bristow Podiatrist and Dean at the Faculty of Podiatric Medicine
Dr Bristow Podiatrist and Dean at the Faculty of Podiatric Medicine, College of Podiatry, London, UK

What are the reasons for dry feet?

Dr Ivan Bristow: There are various reasons why people get dry skin. The most common one is that their skin is aging. The second reason is likely people’s washing regime. The use of soaps, excessive showering or the use of shower gels can easily dry out the skin, with the feet being no exception. Dry skin related to aging and over-bathing is called “physiological dryness.” For people with that sort of dry skin, the use of emollients and moisturizers is very important in order to replenish lost water back into the skin. But there are other possible triggers for dry skin. Fungal infections can be a cause or certain systemic conditions such as diabetes or thyroid problems. It is always important to find the cause of the dry feet.

Graphic of dry skin and graphic of hydrated skin

The new Hansaplast Regenerating Foot Cream features 10% urea. What exactly is urea, and how does it help to smoothen dry feet?


Dr. Ivan Bristow: Urea is a substance that exists naturally in the upper layers of our skin, produced by the body through the breakdown of skin proteins. It plays an important role in the natural moisturizing factor (NMF) complex, keeping the skin constantly moisturized. Additional urea that is applied through a foot cream increases its hydration by attracting and binding water in the upper layers of the skin, known as the epidermis. It basically acts as a binding molecule. This is not only important for maintaining supple skin, but also to strengthen its protective function. In sum, urea is a a highly effective moisturizer.

Why is the Hansaplast Regenerating Foot Cream with 10% UREA such a effective product? What is its unique benefit compared to other products?

Dr. Maike Kuhlmann: The new Hansaplast Regenerating Foot Cream with 10% UREA offers optimal moisturization. It is of great importance to develop a product that perfectly matches the needs of the consumer who want to use the product on a regular basis. This has to include optimal moisturization and excellent skin tolerability, but also a texture that is easy and convenient to use. Our Regenerating Foot Cream has a pleasant scent and is easily absorbed. The high-performance 10% urea formula instantly softens the skin and helps to bind water – reducing dry skin and revealing smooth, beautiful feet.

Maike Kuhlmann
Dr Maike Kuhlmann
Research & Development, Beiersdorf AG

What tests did you perform to assess the new Hansaplast Regenerating Foot Cream’s effectiveness?


Dr. Maike Kuhlmann: The Hansaplast Regenerating Foot Cream with 10% UREA has been tested in dermatological studies. The formula has proven excellent efficacy and skin tolerability on extremely dry skin – for all participants including foot care for diabetics. A dermatological in-use study* demonstrated a significant decrease in skin dryness, scaling, and roughness. Corneometer measurements showed significantly improved skin hydration of 67% after only one week of daily use. And the participants perceived significant benefits from the test product. For example, 94% of all participants stated that the cream reduces the signs of very dry skin. 91% agreed that regular product use strengthens the skin’s protective function. An impressive 100% said the cream provides a smooth skin feeling.

Graphic of 94 per cent
Graphic of 100 per cent

Our tradition of product excellence

Dr Maike Kuhlmann with colleague in lab
Creating high-quality products requires extensive testing and research
Close-up hand applying cream to heel
The cream with 10% urea was tested by consumers and received superior ratings

The dermatological study* conducted with the Hansaplast Regenerating Foot Cream with 10% UREA is one example of how we test our formulas to ensure that each and every product bearing the name Hansaplast is of the best possible quality.

Each product undergoes repeated testing in our labs with regard to various important characteristics, such as stability and other physical qualities. Tolerability, efficacy and various other criteria are then tested in dermatological or clinical studies.

Our commitment to product excellence enables us to determine when a product is right for which set of needs.

Speak to a podiatrist or doctor If you are unsure regarding the severity of your foot skin problems or need advice , we recommend speaking to a podiatrist or a doctor who can help you with your individual needs.

* Dermatological in-use study. 2 weeks, 33 female participants including 19 diabetics. 2013.


For further information regarding Hansaplast products, please contact us via email on phc@beiersdorf.com. Please note that none of the above given tips or recommendations substitute medical advice. Carefully read the instructions for use given in our products‘ packages. Consult a health professional if our tips won‘t help or in case you have or suspect a medical condition.
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